Sphingolipid Synthesis as a Target for Antifungal Drugs
نویسندگان
چکیده
منابع مشابه
Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene.
We have identified a Saccharomyces cerevisiae gene necessary for the step in sphingolipid synthesis in which inositol phosphate is added to ceramide to form inositol-P-ceramide, a reaction catalyzed by phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase). This step should be an effective target for antifungal drugs. A key element in our experiments was the development of a p...
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Working in the medium of batik, Paul Nzalamba creates images that are drawn from his native country, Uganda, and that reflect the strength, struggle, and beauty of all people, especially children and adolescents. We chose to use his “At Play” (1988) to show a modern, indigenous artist’s work that illustrates the color and joy of such artists. Mr. Nzalamba’s works are on display at his studio in...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1997
ISSN: 0021-9258
DOI: 10.1074/jbc.272.15.9809